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The Port Elizabeth Regional Chamber of Commerce and Industry (PERCCI) was established in 1994 with a view to fostering, encouraging, promoting, protecting, developing and establishing commercial and industrial enterprises within the Port Elizabeth and Uitenhage Metropole (now Nelson Mandela Bay).  This is achieved through the provision of services to business in the form of information, communication, seminars, task teams, networking functions and a strong international trade focus.  Lobbying, representation and strategic interventions are also key focus areas, with the objective of facilitating an environment which is conducive to economic growth.

PERCCI is a non-profit business association, representative of a broad spectrum of businesses in Nelson Mandela Bay.  It is the largest business association in the Eastern Cape with a membership of close to 1 000 businesses. The Chamber is fully representative of the demographics of the business sector.  It is leading business transformation by example, in its staff, Board and membership equity spread.

These functions had previously been provided by the Port Elizabeth Chamber of Commerce (established in 1864) and the Midland Chamber of Industry (established in 1927).  The amalgamation of these two Chambers has significantly strengthened the voice of organised business in the city.